Δρ. Γιώργος Βαρθολομάτος

Δρ. Γιώργος Βαρθολομάτος

Επιστημονικός υπεύθυνος του Αιματολογικού Εργαστηρίου του Τμήματος Μοριακής Βιολογίας, Περιφερειακό Πανεπιστημιακό Νοσοκομείο Ιωαννίνων.

  • BcS Biochemistry, Institute of Polytechnic Bucharest 1985
  • PhD Biochemistry and Molecular Genetics, University of Ioannina, Greece 1995
  • Visiting post-graduate, University of California, Berkeley, 1993
  • Post -Doc, Department of Chemistry, University of Ioannina 1995 – 1997
 
  • Teaching Assistant, Department of Chemistry, University of Ioannina 1990-1995.
  • Scientific Responsible of the Unit of Molecular Biology –Haematology Laboratory, Regional University Hospital of Ioannina. 1997-today.
  • Contract Assistant Professor, Department of Biological Applications and Technologies, University of Ioannina. 2000-2005.

Molecular diagnosis of mutations related with thrombophilia (venous thromboembolism and arterial thrombosis), hereditary heamochromatosis, different translocations in cases of acute leukemia with RT-PCR, diagnosis by flow cytometry of heamatological malignances (e.g. acute leukaemia, B, T or AML, T-CLL, B-CLL, PNH, etc.) and inherited or acquired platelet disorders. Also, diagnosis of minimal residual disease, by flow cytometry and PCR techniques on haematological treated patients, and

last 15 years focus on iFC ( Intraoperative Flow Cytometry).

Participation in Heamatology Congresses (National, European, and World wide), Flow Cytometry Congresses and Seminars on Clinical Biochemistry and Heamatology of the University Ioannina Hospital.

  • General Secretariat of Research & Technology GR, PENED 1989
  • STRIDE HELLAS 33
  • EC, DGXII, Biotech 1993 (BIO2-CT93-0274)
  • EC, DGXII, Biotech 1995 (BIO4-CT95-4807)
  • Greek Society of Endocrinology
  • Research Committee of the University of Ioannina
  • Ministry of Education, EPEAEK “Herakleitos” 2003-2005
  • General Secretariat of Research & Technology GR, PENED 2003-2006
  • Ministry of Education, EPEAEK “Archimides” 2004-2006
  • Union of Greek Chemists, full member since 1985
  • Hellenic Society of Biochemistry and Molecular Biology, full member since 1995
  • Hellenic Society for Flow Cytometry, full member since 1998
  • European Society for Analytical Cellular Pathology, full member 1999
  • Hellenic Society of Heamatology, corresponding member since 1999
  • Hellenic Society of Clinical Chemistry-Clinical Biochemistry, full member since 2003

Lectures in Biochemistry as contract Assistant Professor in the Department of Biological Applications and Technology, University of Ioannina, 2000-2005, and writing Laboratory notes for Biochemistry classes I and II.

Invited speaker in many National Congresses and Seminars in Flow Cytometry, Heamatology and Clinical Chemistry.

  • 9th BCLF Meeting, Balkan Clinical Laboratories Foundation, 12-15 September 2001, Ioannina, member of Organizing Committee
  • 2nd Panhellenic Symposium of Flow Cytometry, 16-19 May, 2002, Rhodos, member of Organizing Committee
  • “Flow Cytometry in diagnosis of heamatological diseases”, under the auspices of Hellenic Society for Flow Cytometry, Scientific Meeting, Ioannina, 11th October, 2003, Chairman of the Organizing Committee
  • 3nd Panhellenic Symposium of Flow Cytometry, 13-16 May, 2004, Myconos, treasurer of the Organizing Committee.
  • 6th Panhellenic Symposium of Flow Cytometry, 16-19 May, 2002, Rhodos, president of Organizing Committee
  1. Vartholomatos G, Alexiou GA, Voulgaris S, Kyritsis AP. Intraoperative Immunophenotypic Analysis for Diagnosis and Classification of Primary Central Nervous System Lymphomas. World Neurosurg. 2018 Sep;117: 464-465.
  2. Vartholomatos G, Alexiou GA, Lianos GD, Harissis H, Voulgaris S, Kyritsis AP. Intraoperative cell cycle analysis for tumor margins evaluation: The future is now? Int J Surg. 2018 May;53:380-381.
  3. Benetatos L, Vartholomatos G. Enhancer DNA methylation in acute myeloid leukemia and myelodysplastic syndromes. Cell Mol Life Sci. 2018 Jun;75(11):1999-2009.
  4. Mitsis M, Koliou P, Bali C, Ntounousi E, Tatsis V, Nousias V, Lianos GD, Vartholomatos G, Nastos D. In Surgical Colon Cancer Patients Extended-Duration Thromboprophylaxis (30 days) with the Highest Dose of Tinzaparin (4,500 IU s.c./q.d.) Normalizes the Postoperative VEGF Levels. J Cancer. 2017 Aug 25;8(15):2899-2906.
  5. Markopoulos GS, Roupakia E, Tokamani M, Vartholomatos G, Tzavaras T, Hatziapostolou M, Fackelmayer FO, Sandaltzopoulos R, Polytarchou C, Kolettas E. Senescence-associated microRNAs target cell cycle regulatory genes in normal human lung fibroblasts. Exp Gerontol. 2017 Oct 1;96:110-122.
  6. Alexiou GA, Vartholomatos G, Markopoulos GS, Voulgaris S, Kyritsis AP. Effectiveness of flow cytometry for brain tumor excision. Photodiagnosis Photodyn Ther. 2017 Jun;18:323-324
  7. Benetatos L, Voulgaris E, Vartholomatos G. The crosstalk between long non-coding RNAs and PI3K in cancer. Med Oncol. 2017 Mar;34(3):39.
  8. Lazaros L, Kitsou C, Kostoulas C, Bellou S, Hatzi E, Ladias P, Stefos T, Markoula S, Galani V, Vartholomatos G, Tzavaras T, Georgiou I. Retrotransposon expression and incorporation of cloned human and mouse retroelements in human spermatozoa. Fertil Steril. 2017 Mar;107(3):821-830.
  9. Vartholomatos G, Alexiou GA, Lianos GD, Kyritsis AP. From bench to operating theater: has the time come for a molecular scalpel? Future Oncol. 2017 Jan;13(2):121-123.
  10. Papoudou-Bai A, Vassou A, Vartholomatos G, Briasoulis E, Kanavaros P. Composite hairy cell leukemia and chronic lymphocytic leukemia. J BUON. 2016 Jul-Aug;21(4):1027-1029.
  11. Kitsou C, Lazaros L, Bellou S, Vartholomatos G, Sakaloglou P, Hatzi E, Markoula S, Zikopoulos K, Tzavaras T, Georgiou I. Exogenous retroelement integration in sperm and embryos affects preimplantation development. Reproduction. 2016 Sep;152(3):185-93.
  12. Markopoulos G, Noutsopoulos D, Mantziou S, Gerogiannis D, Thrasyvoulou S, Vartholomatos G, Kolettas E, Tzavaras T. Genomic analysis of mouse VL30 retrotransposons. Mob DNA. 2016 May 6;7:10
  13. Benetatos L, Vartholomatos G. On the potential role of DNMT1 in acute myeloid leukemia and myelodysplastic syndromes: not another mutated epigenetic driver. Ann Hematol. 2016 Oct;95(10):1571-82
  14. Alexiou GA, Vartholomatos G, Voulgaris S, Kyritsis AP. Letter: Glioblastoma Resection Guided by Flow Cytometry. Neurosurgery. 2016 May;78(5):E761
  15. Alexiou GA, Vartholomatos G, Voulgaris S, Kyritsis AP. Letter to the Editor: Intraoperative detection of glioma cells by flow cytometry. J Neurosurg. 2016 Feb;124(2):587-8.
  16. Zikou A, Alexiou GA, Vartholomatos G, Goussia A, Xydis VG, Kosta P, Voulgaris S, Kyritsis AP, Argyropoulou MI. Correlation of diffusion tensor and dynamic susceptibility contrast MRI with DNA ploidy and cell cycle analysis of gliomas. Clin Neurol Neurosurg. 2015 Dec;139:119-24.
  17. Alexiou GA, Vartholomatos G, Stefanaki K, Lykoudis EG, Patereli A, Tseka G, Tzoufi M, Sfakianos G, Prodromou N. The Role of Fast Cell Cycle Analysis in Pediatric Brain Tumors. Pediatr Neurosurg. 2015;50(5):257-63.
  18. Arnaoutoglou E, Kouvelos G, Papa N, Karamoutsios A, Bouris V, Vartholomatos G, Matsagkas M. Platelet activation after endovascular repair of abdominal aortic aneurysm. Vascular. 2016 Jun;24(3):287-94.
  19. Ovrenovits M, Pakos EE, Vartholomatos G, Paschos NK, Xenakis TA, Mitsionis GI. Flow cytometry as a diagnostic tool for identifying total hip arthroplasty loosening and differentiating between septic and aseptic cases. Eur J Orthop Surg Traumatol. 2015 Oct;25(7):1153-9.
  20. Vartholomatos G, Alexiou GA, Batistatou A, Lykoudis E, Voulgaris S, Kyritsis AP. GV/GA Sarissa-Lancet: A Proposed Real-Time Flow Cytometer for Intraoperative Identification of Glioma Margins. Surg Innov. 2016 Feb;23(1):104-5.
  21. Vartholomatos G, Alexiou GA, Stefanaki K, Lykoudis EG, Tseka G, Tzoufi M, Sfakianos G, Prodromou N. The value of cell cycle analysis by propidium-iodine staining of CD56+ cells in pediatric brain tumors. Clin Neurol Neurosurg. 2015 Jun;133:70-4.
  22. Vartholomatos G, Alexiou GA, Gerogianni P, Lykoudis E, Voulgaris S, Kyritsis AP. Is there a role for intraoperative flow cytometry in brain tumor surgery? Cytometry B Clin Cytom. 2015 Sep-Oct;88(5):289-90
  23. Benetatos L, Vartholomatos G. Imprinted genes in myeloid lineage commitment in normal and malignant hematopoiesis. 2015 Jun;29(6):1233-42.
  24. Vartholomatos G, Alexiou GA, Batistatou A, Lykoudis E, Voulgaris S, Kyritsis AP. Rapid cell cycle analysis for intraoperative diagnosis of brain tumors. Brain Tumor Pathol. 2015 Apr;32(2):151-2.
  25. Alexiou GA, Karamoutsios A, Lallas G, Ragos V, Goussia A, Kyritsis AP, Voulgaris S, Vartholomatos G. Expression of heat shock proteins in brain tumors. Turk Neurosurg. 2014;24(5):745-9.
  26. Alexiou GA, Vartholomatos G, Goussia A, Batistatou A, Tsamis K, Voulgaris S, Kyritsis AP. Fast cell cycle analysis for intraoperative characterization of brain tumor margins and malignancy. J Clin Neurosci. 2015 Jan;22(1):129-32.
  27. Vartholomatos G, Alexiou G, Batistatou A, Kyritsis AP. Intraoperative cell-cycle analysis to guide brain tumor removal. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3755.
  28. Benetatos L, Vartholomatos G, Hatzimichael E. DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist. Cell Mol Life Sci. 2014 Nov;71(22):4421-30.
  29. Gousias K, Voulgaris S, Vartholomatos G, Voulgari P, Kyritsis AP, Markou M. Prognostic value of the preoperative immunological profile in patients with glioblastoma. Surg Neurol Int. 2014 Jun 7;5:89.
  30. Chondrogiannis G, Kastamoulas M, Kanavaros P, Vartholomatos G, Bai M, Baltogiannis D, Sofikitis N, Arvanitis D, Galani V. Cytokine effects on cell viability and death of prostate carcinoma cells. Biomed Res Int. 2014;2014:536049.
  31. Sigounas DE, Christodoulou DK, Karamoutsios A, Tatsioni A, Dova L, Vartholomatos G, Kolaitis N, Katsanos KH, Zervou E, Ioannidis JP, Tsianos EV. Changes of serum adhesion molecules and cytokines in post-ERCP pancreatitis: adhesion molecules and cytokines in acute pancreatitis. Clin Biochem. 2014 Sep;47(13-14):1245-9.
  32. Chatzistefanidis D, Giannopoulos S, Spengos K, Vassilopoulou S, Vemmos K, Dova L, Vartholomatos G, Kyritsis AP, Georgiou I, Markoula S. Apolipoprotein E polymorphisms and ischaemic stroke: a two-center Greek study. Eur J Neurol. 2014 Aug;21(8):1083-1088
  33. Alexiou GA, Vartholomatos G, Stefanaki K, Patereli A, Dova L, Karamoutsios A, Lallas G, Sfakianos G, Moschovi M, Prodromou N. Expression of heat shock proteins in medulloblastoma. J Neurosurg Pediatr. 2013 Nov;12(5):452-7.
  34. Benetatos L, Vartholomatos G, Hatzimichael E. Polycomb group proteins and MYC: the cancer connection. Cell Mol Life Sci. 2014 Jan;71(2):257-69.
  35. Karamani AA, Fiamegos YCh, Vartholomatos G, Stalikas CD. Fluoroacetylation/fluoroethylesterification as a derivatization approach for gas chromatography-mass spectrometry in metabolomics: preliminary study of lymphohyperplastic diseases. J Chromatogr A. 2013 Aug 9;1302:125-32.
  36. Benetatos L, Vartholomatos G. MicroRNAs mark in the MLL-rearranged leukemia. Ann Hematol. 2013 Nov;92(11):1439-50.
  37. Vartholomatos G, Alexiou GA, Batistatou A, Kyritsis AP, Voulgaris S. Intraoperative diagnosis. J Neurosurg. 2013 Aug;119(2):528-30.
  38. Markopoulos G, Noutsopoulos D, Mantziou S, Vartholomatos G, Monokrousos N, Angelidis C, Tzavaras T. Arsenic induces VL30 retrotransposition: the involvement of oxidative stress and heat-shock protein 70. Toxicol Sci. 2013 Aug;134(2):312-22.
  39. Drougia AA, Zikou AK, Vartholomatos GA, Argyropoulou MI, Andronikou SK. Cerebral venous sinus thrombosis in a pre-term neonate diagnosed by MR-venography. J Obstet Gynaecol. 2013 May;33(4):415.
  40. Lazaros L, Vartholomatos G, Pamporaki C, Kosmas I, Takenaka A, Makrydimas G, Sofikitis N, Stefos T, Zikopoulos K, Hatzi E, Georgiou I. Sperm flow cytometric parameters are associated with ICSI outcome. Reprod Biomed Online. 2013 Jun;26(6):611-8.
  41. Kastamoulas M, Chondrogiannis G, Kanavaros P, Vartholomatos G, Bai M, Briasoulis E, Arvanitis D, Galani V. Cytokine effects on cell survival and death of A549 lung carcinoma cells. Cytokine. 2013 Mar;61(3):816-25.
  42. Alexiou GA, Stefanaki K, Vartholomatos G, Sfakianos G, Prodromou N, Moschovi M. Embryonal tumor with abundant neuropil and true rosettes: a systematic literature review and report of 2 new cases. J Child Neurol. 2013 Dec;28(12):1709-15.
  43. Yioti GG, Panagiotou OA, Vartholomatos GA, Kolaitis NI, Pappa CN, Evangelou E, Stefaniotou MI. Genetic polymorphisms associated with retinal vein occlusion: a Greek case-control study and meta-analysis. Ophthalmic Genet. 2013 Sep;34(3):130-9.
  44. Benetatos L, Voulgaris E, Vartholomatos G, Hatzimichael E. Non-coding RNAs and EZH2 interactions in cancer: long and short tales from the transcriptome. Int J Cancer. 2013 Jul 15;133(2):267-74.
  45. Benetatos L, Hatzimichael E, Londin E, Vartholomatos G, Loher P, Rigoutsos I, Briasoulis E. The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis. Cell Mol Life Sci. 2013 Mar;70(5):795-814.
  46. Alexiou GA, Vartholomatos G, Karamoutsios A, Voulgaris S. The role of circulating progenitor cells in glioma patients. J Neurooncol. 2012 Oct;110(1):153-4.
  47. Sfikas A, Batsi C, Tselikou E, Vartholomatos G, Monokrousos N, Pappas P, Christoforidis S, Tzavaras T, Kanavaros P, Gorgoulis VG, Marcu KB, Kolettas E. The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage. Cell Signal. 2012 Nov;24(11):2007-23.
  48. Alexiou GA, Vartholomatos G, Karamoutsios A, Batistatou A, Kyritsis AP, Voulgaris S. Circulating progenitor cells: a comparison of patients with glioblastoma or meningioma.
  49. Acta Neurol Belg. 2013 Mar;113(1):7-11.
  50. Petsa PK, Karamoutsios A, Dova L, Benetatos L, Petsiou A, Kolaitis N, Georgopoulos A, Vartholomatos G. Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype. Clin Pract. 2012 Jun 27;2(3):e68
  51. Konisti S, Mantziou S, Markopoulos G, Thrasyvoulou S, Vartholomatos G, Sainis I, Kolettas E, Noutsopoulos D, Tzavaras. T. H2O2 signals via iron induction of VL30 retrotransposition correlated with cytotoxicity. Free Radic Biol Med. 2012 May 15;52(10):2072-81.
  52. Benetatos L, Voulgaris E, Vartholomatos G. DLK1-MEG3 imprinted domain microRNAs in cancer biology. Crit Rev Eukaryot Gene Expr. 2012;22(1):1-15.
  53. Benetatos L, Vartholomatos G. Deregulated microRNAs in multiple myeloma. 2012 Feb 15;118(4):878-87.